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.topic-grid{grid-template-columns:repeat(auto-fit,minmax(240px,1fr))}
.pinned-article{padding:0 0 76px;background:var(--paper)}
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.home-half-life{padding:0 0 76px;background:var(--paper)}
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.home-half-life__preview small{display:block;margin-top:17px;padding-top:14px;border-top:1px solid #41635f;color:#91aba3;font-size:10px;line-height:1.45}

.warning-feature{position:relative;overflow:hidden;padding:58px 0 62px;background:#6f211b;color:#fff6ec;border-top:8px solid #f2a84a;border-bottom:8px solid #f2a84a;box-shadow:inset 0 1px rgba(255,255,255,.2),inset 0 -1px rgba(0,0,0,.25)}
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.warning-feature__cta:hover{transform:translate(-2px,-2px);box-shadow:6px 6px 0 #43120f;text-decoration:underline}
.medicine-feature{padding:76px 0 80px;background:#143747;color:#edf5f2;border-bottom:1px solid #0c2935}
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.medicine-feature h2{max-width:720px;margin:0;color:#fff;font:400 clamp(42px,5vw,60px)/.98 var(--serif);letter-spacing:-1.6px}
.medicine-feature__lead{max-width:760px;margin:23px 0 27px;color:#d7e5e1;font-size:17px;line-height:1.58}
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.medicine-feature__cta:hover{color:#f6dca7}
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.medicine-feature__related a:hover{transform:translateY(-2px);background:#fffdf9;border-color:#f1c56e;box-shadow:0 6px 15px rgba(3,18,24,.22)}
.medicine-feature__related a:focus-visible{outline:3px solid #f1c56e;outline-offset:2px}
.medicine-feature__related i{color:#a94f35;font-size:19px;font-style:normal}
.medicine-feature__facts{border-top:1px solid rgba(255,255,255,.3)}
.medicine-feature__facts>div{display:grid;grid-template-columns:42px 1fr;gap:14px;padding:19px 0;border-bottom:1px solid rgba(255,255,255,.22)}
.medicine-feature__facts span{padding-top:4px;color:#f1c56e;font:500 11px/1 var(--mono)}
.medicine-feature__facts p{margin:0;color:#d7e5e1;font-size:13px;line-height:1.48}
.medicine-feature__facts strong{display:block;margin-bottom:3px;color:#fff;font-size:14px}
.prose h3{margin:31px 0 12px;color:var(--ink);font:600 23px/1.25 var(--sans);letter-spacing:-.3px}
.prose blockquote{margin:27px 0;padding:17px 20px;background:#edf3ef;border-left:4px solid #86a99f;color:var(--ink);font-size:16px;line-height:1.58}
.article-page--warning .prose blockquote{margin:30px 0;padding:20px 22px;background:#fff1cf;border-left:5px solid #d9533f;color:#54201c}
.prose a{color:#145d58;text-decoration-thickness:1px;text-underline-offset:3px}
.prose-table-wrap{overflow-x:auto;margin:30px 0 34px;border:1px solid var(--line);background:#fff}
.prose-table{width:100%;min-width:760px;border-collapse:collapse;font-size:14px;line-height:1.48}
.prose-table caption{padding:14px 16px;background:#e7efeb;color:var(--ink);text-align:left;font:600 12px/1.35 var(--mono)}
.prose-table th,.prose-table td{padding:15px 16px;border-right:1px solid var(--line);border-bottom:1px solid var(--line);text-align:left;vertical-align:top}
.prose-table thead th{background:#173c3b;color:#fff;font-size:12px}
.prose-table tbody th{width:150px;background:#f8f6f1;color:var(--ink);font-weight:700}
.prose-table tr:last-child th,.prose-table tr:last-child td{border-bottom:0}
.prose-table th:last-child,.prose-table td:last-child{border-right:0}
.half-life-chart{margin:31px 0 36px;padding:25px 27px 27px;background:#edf3ef;border:1px solid #cbdad4;color:var(--ink)}
.half-life-chart figcaption{margin-bottom:19px;font:400 28px/1.1 var(--serif)}
.half-life-chart__controls{display:grid;grid-template-columns:minmax(0,1fr) 190px;gap:10px 22px;align-items:center;margin-bottom:25px;padding-bottom:21px;border-bottom:1px solid #bfd0ca}
.half-life-chart__controls label{font-size:14px;font-weight:600}
.half-life-chart__controls input{width:100%;accent-color:var(--orange)}
.half-life-chart__controls p{grid-column:1/-1;margin:0;color:#526d68;font-size:12px}
.half-life-chart__controls output,.half-life-chart__controls strong{color:#a94f35}
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.half-life-chart__axis{display:flex;justify-content:space-between;margin:0 118px -9px 168px;color:#71857f;font:9px/1.2 var(--mono);text-transform:uppercase;letter-spacing:.4px}
.half-life-chart__row{display:grid;grid-template-columns:155px minmax(100px,1fr) 105px;gap:13px;align-items:center}
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.half-life-chart__label strong{font-size:13px}
.half-life-chart__label span{color:#687d77;font:10px/1.35 var(--mono)}
.half-life-chart__track{position:relative;height:12px;background:#d8e4df}
.half-life-chart__track span{position:absolute;inset:0 auto 0 0;min-width:5px;background:linear-gradient(90deg,#d26040,#e99a67);transition:width .18s ease}
.half-life-chart__track i{position:absolute;top:-4px;width:2px;height:20px;background:var(--ink);transform:translateX(-1px);transition:left .18s ease}
.half-life-chart__value{text-align:right;color:#375b56;font:11px/1.3 var(--mono)}
.half-life-chart__note{margin:23px 0 0!important;padding-top:17px;border-top:1px solid #bfd0ca;color:#526d68;font-size:12px;line-height:1.55}

.site-header nav a.nav-search{display:inline-flex;align-items:center;justify-content:center;margin:-9px 0;padding:9px 14px;background:var(--ink);color:#fff;font-weight:600}
.site-header nav a.nav-search:hover{background:var(--orange);text-decoration:none}

.directory-callout{display:flex;align-items:center;justify-content:space-between;gap:32px;margin-top:28px;padding:27px 29px;background:var(--paper);border:1px solid #cbdad4;border-left:4px solid var(--orange)}
.directory-callout h3{margin:0 0 7px;color:var(--ink);font:400 30px/1.08 var(--serif)}
.directory-callout p:not(.eyebrow){margin:0;color:var(--muted);font-size:14px}
.directory-callout .button{flex:none}
.directory-header p{max-width:680px}
.directory-summary{display:flex;gap:11px;margin-top:27px}
.directory-summary span{padding:8px 12px;background:#fff;border:1px solid var(--line);color:var(--muted);font:12px/1.2 var(--mono)}
.directory-summary strong{color:var(--ink);font-weight:600}
.directory-section{padding:52px 0 92px}
.site-search{scroll-margin-top:20px;margin-bottom:24px;padding:27px 31px 31px;background:var(--ink);border-top:5px solid var(--orange);color:#fff;box-shadow:0 12px 28px rgba(23,60,59,.14)}
.site-search__eyebrow{margin:0 0 9px;color:#f1c56e;text-transform:uppercase;font:500 10px/1.2 var(--mono);letter-spacing:1px}
.site-search>label{display:block;margin-bottom:13px;font:400 31px/1.1 var(--serif)}
.site-search__controls{display:grid;grid-template-columns:minmax(0,1fr) auto}
.site-search input{min-width:0;height:54px;padding:0 17px;border:2px solid #fff;border-radius:0;background:#fff;color:var(--ink);font:16px var(--sans);outline:none}
.site-search input:focus{border-color:#f1c56e;box-shadow:inset 0 0 0 1px #f1c56e}
.site-search button{min-width:122px;border:0;background:var(--orange);color:#fff;font:600 14px var(--sans);cursor:pointer}
.site-search button:hover{background:#c85d3b}
.site-search__meta{display:flex;align-items:center;justify-content:space-between;gap:20px;margin-top:11px;color:#c7d7d2;font-size:12px}
.site-search__meta p{margin:0}
.site-search__meta output{flex:none;color:#f1c56e;font:500 12px var(--mono)}
.directory-jumps{display:flex;align-items:center;gap:9px;flex-wrap:wrap;margin-bottom:49px;padding-bottom:23px;border-bottom:1px solid var(--line)}
.directory-jumps span{margin-right:4px;color:var(--muted);font:11px var(--mono);text-transform:uppercase;letter-spacing:.7px}
.directory-jumps a{padding:7px 10px;background:var(--cream);border:1px solid var(--line);color:var(--ink);font-size:12px;text-decoration:none}
.directory-jumps a:hover{border-color:#86a99f;text-decoration:underline}
.topic-index-group{scroll-margin-top:20px;margin-bottom:62px}
.topic-index-group__header{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:32px;align-items:end;margin-bottom:20px}
.topic-index-group__header h2{margin:0 0 8px;font:400 42px/1.05 var(--serif);letter-spacing:-.7px}
.topic-index-group__header h2 a{color:var(--ink);text-decoration:none}
.topic-index-group__header h2 a:hover{text-decoration:underline;text-decoration-thickness:1px;text-underline-offset:5px}
.topic-index-group__header p:not(.eyebrow){max-width:650px;margin:0;color:var(--muted);font-size:14px}
.topic-index-group__header>span{padding-bottom:4px;color:var(--muted);font:11px var(--mono)}
.topic-index-list{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));margin:0;padding:0;border-top:1px solid var(--ink);list-style:none}
.topic-index-item{border-bottom:1px solid var(--line)}
.topic-index-item:nth-child(odd){border-right:1px solid var(--line)}
.topic-index-item a{display:grid;grid-template-columns:34px minmax(0,1fr) 20px;gap:10px;align-items:start;min-height:78px;padding:17px 16px 16px 4px;color:var(--ink);text-decoration:none}
.topic-index-item a:hover{background:#edf3ef}
.topic-index-item__number{padding-top:3px;color:#a26049;font:10px var(--mono)}
.topic-index-item__title{font:500 15px/1.45 var(--sans)}
.topic-index-item__arrow{color:var(--orange);font-size:18px}
.search-empty{margin:0;padding:32px;background:var(--cream);border-left:4px solid var(--orange);color:var(--ink);font-size:17px}

.featured-guides{padding:76px 0 82px;background:#e5efeb;border-bottom:1px solid #cbdcd5}
.featured-guides__heading{display:grid;grid-template-columns:minmax(0,1.15fr) minmax(280px,.65fr);gap:64px;align-items:end;margin-bottom:32px}
.featured-guides__heading h2{max-width:700px;margin:0;color:var(--ink-deep);font:400 clamp(42px,5vw,58px)/1 var(--serif);letter-spacing:-1.5px}
.featured-guides__heading>p{margin:0;color:#526d68;font-size:15px;line-height:1.58}
.featured-guides__grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px}
.featured-guide-card{position:relative;display:flex;flex-direction:column;min-height:410px;padding:28px 30px 27px;background:var(--paper);border:1px solid #bfcfc9;box-shadow:inset 0 4px #d56a47;transition:transform .2s,box-shadow .2s}
.featured-guide-card:nth-child(2){box-shadow:inset 0 4px #557f76}
.featured-guide-card:hover{transform:translateY(-3px);box-shadow:inset 0 4px #d56a47,0 10px 24px rgba(23,60,59,.09)}
.featured-guide-card:nth-child(2):hover{box-shadow:inset 0 4px #557f76,0 10px 24px rgba(23,60,59,.09)}
.featured-guide-card__top{display:flex;align-items:center;justify-content:space-between;padding-bottom:20px;border-bottom:1px solid var(--line)}
.featured-guide-card__top p{margin:0;color:#a94f35;text-transform:uppercase;font:500 11px/1.2 var(--mono);letter-spacing:.9px}
.featured-guide-card:nth-child(2) .featured-guide-card__top p{color:#416d65}
.featured-guide-card__top span{color:#9caeaa;font:12px/1 var(--mono)}
.featured-guide-card h3{margin:25px 0 15px;color:var(--ink-deep);font:400 clamp(31px,3.3vw,41px)/1.02 var(--serif);letter-spacing:-.8px}
.featured-guide-card h3 a{color:inherit;text-decoration:none}
.featured-guide-card h3 a:hover{text-decoration:underline;text-decoration-thickness:1px;text-underline-offset:4px}
.featured-guide-card>p{margin:0 0 25px;color:#5c716d;font-size:14px;line-height:1.58}
.featured-guide-card__cta{display:flex;align-items:center;justify-content:space-between;margin-top:auto;padding-top:16px;border-top:1px solid var(--line);color:var(--ink);font-size:13px;font-weight:600;text-decoration:none}
.featured-guide-card__cta:hover{text-decoration:underline}

.privacy-section{padding:82px 0 86px;background:#dce9e4;border-top:1px solid #c6d8d1}
.privacy-section__inner{display:grid;grid-template-columns:150px minmax(0,1fr);gap:55px;align-items:start}
.privacy-section__seal{width:132px;height:132px;display:flex;flex-direction:column;align-items:center;justify-content:center;border:1px solid #77958c;border-radius:50%;color:var(--ink);box-shadow:0 0 0 9px rgba(23,60,59,.055)}
.privacy-section__seal strong{font:400 55px/.78 var(--serif)}
.privacy-section__seal span{margin-top:9px;text-transform:uppercase;font:500 9px/1 var(--mono);letter-spacing:1px}
.privacy-section__content h2{margin:0;color:var(--ink-deep);font:400 clamp(44px,5vw,60px)/.98 var(--serif);letter-spacing:-1.5px}
.privacy-section__lead{max-width:780px;margin:19px 0 29px;color:#4f6963;font-size:17px;line-height:1.55}
.privacy-section__content ul{display:grid;grid-template-columns:repeat(3,1fr);gap:0;margin:0;padding:0;list-style:none;border-top:1px solid #abc1b9;border-bottom:1px solid #abc1b9}
.privacy-section__content li{padding:18px 22px 19px 0}
.privacy-section__content li+li{padding-left:22px;border-left:1px solid #abc1b9}
.privacy-section__content li strong,.privacy-section__content li span{display:block}
.privacy-section__content li strong{margin-bottom:4px;color:var(--ink);font-size:13px}
.privacy-section__content li span{color:#637873;font-size:12px;line-height:1.45}

@media(max-width:760px){.site-header{position:sticky;top:0;z-index:30;box-shadow:0 5px 16px rgba(16,47,47,.11);backdrop-filter:blur(9px)}.site-header nav{gap:9px}.site-header nav a.nav-search{min-height:42px;margin:0;padding:0 14px;background:var(--orange)}.pinned-article{padding-bottom:58px}.pinned-article__inner{grid-template-columns:1fr;gap:27px;padding:43px 24px 28px;border-left-width:4px}.pinned-article__label{left:18px}.pinned-article__content h2{font-size:41px}.pinned-article__comparison{padding:24px 0 0;border-left:0;border-top:1px solid #cfbea4}.home-half-life{padding-bottom:58px}.home-half-life__inner{grid-template-columns:1fr;gap:31px;padding:34px 23px 27px}.home-half-life h2{font-size:39px}.home-half-life__preview{padding:20px 17px}.home-half-life__preview>div{grid-template-columns:82px minmax(60px,1fr) 61px;gap:8px}.warning-feature{padding:43px 0 47px;border-width:6px}.warning-feature__inner{grid-template-columns:1fr;gap:23px}.warning-feature__mark{width:67px;height:67px;font-size:50px}.warning-feature h2{font-size:42px;letter-spacing:-1px}.warning-feature__lead{font-size:16px}.warning-feature__checklist{grid-template-columns:1fr}.warning-feature__checklist li{min-height:0}.warning-feature__cta{width:100%;justify-content:space-between}.medicine-feature{padding:51px 0 56px}.medicine-feature__inner{grid-template-columns:1fr;gap:35px}.medicine-feature h2{font-size:42px;letter-spacing:-1px}.medicine-feature__lead{font-size:16px}.medicine-feature__related{grid-template-columns:1fr;padding:14px}.medicine-feature__related a{min-height:0}.medicine-feature__facts>div{grid-template-columns:35px 1fr}.featured-guides{padding:56px 0 61px}.featured-guides__heading{grid-template-columns:1fr;gap:18px}.featured-guides__heading h2{font-size:41px}.featured-guides__grid{grid-template-columns:1fr}.featured-guide-card{min-height:0;padding:25px 23px}.featured-guide-card h3{font-size:34px}.privacy-section{padding:59px 0 63px}.privacy-section__inner{grid-template-columns:1fr;gap:30px}.privacy-section__seal{width:104px;height:104px}.privacy-section__content h2{font-size:43px}.privacy-section__lead{font-size:16px}.privacy-section__content ul{grid-template-columns:1fr}.privacy-section__content li{padding:16px 0}.privacy-section__content li+li{padding-left:0;border-left:0;border-top:1px solid #abc1b9}.prose h3{font-size:21px}.half-life-chart{margin-left:-8px;margin-right:-8px;padding:21px 18px}.half-life-chart__controls{grid-template-columns:1fr}.half-life-chart__controls input{grid-row:2}.half-life-chart__axis{margin-left:114px;margin-right:0}.half-life-chart__row{grid-template-columns:105px minmax(70px,1fr);gap:9px}.half-life-chart__value{grid-column:2;text-align:left}.directory-callout{display:block;padding:23px 21px}.directory-callout .button{width:100%;justify-content:space-between;margin-top:20px}.directory-summary{flex-wrap:wrap}.directory-section{padding:35px 0 62px}.site-search{scroll-margin-top:86px;margin:0 -8px 28px;padding:21px 20px 23px;border-top-width:6px;box-shadow:0 14px 30px rgba(16,47,47,.2)}.site-search>label{font-size:29px}.site-search__controls{grid-template-columns:1fr}.site-search input{width:100%;height:56px}.site-search button{height:52px;font-size:15px}.site-search__meta{align-items:flex-start}.site-search__meta p{max-width:75%}.directory-jumps{margin-bottom:39px}.topic-index-group{scroll-margin-top:84px;margin-bottom:48px}.topic-index-group__header{grid-template-columns:1fr;gap:8px}.topic-index-group__header h2{font-size:36px}.topic-index-list{grid-template-columns:1fr}.topic-index-item:nth-child(odd){border-right:0}.topic-index-item a{min-height:0;padding-right:9px}.search-empty{padding:24px 21px}}
@media(max-width:420px){.site-header nav a:first-child{display:none}.site-header nav a.nav-search{display:inline-flex}}